Observation of the acceleration of a single bunch by using the induction device in the kek proton synchrotron

A single rf bunch in the KEK proton synchrotron was accelerated with an induction acceleration method from the injection energy of 500 MeV to 5 GeV.</p

Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review

The blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS). The BBB endothelial cells have well-developed tight junctions (TJs) and express specific polarized transport systems to tightly control the paracellular movements of solutes, ions, and water. There are two types of TJs: bicellular TJs (bTJs), which is a structure at the contact of two cells, and tricellular TJs (tTJs), which is a structure at the contact of three cells. Claudin-5 and angulin-1 are important components of bTJs and tTJs in the brain, respectively. Here, we review TJ-modulating bioprobes that enable drug delivery to the brain across the BBB, focusing on claudin-5 and angulin-1

All-ion accelerators: An injector-free synchrotron

A medium-energy synchrotron capable of accelerating all-ion species is proposed. The accelerator employs a strong focusing lattice for ion-beam guiding and induction acceleration for acceleration and longitudinal capture, which is driven by a switching power supply. All ions, including cluster ions in their possible and arbitrary charge state, are accelerated in a single accelerator. Since the switching power supply employing solid-state switching elements is energized by a trigger signal, which is generated from a bunch monitor signal produced by a circulating ion bunch, the induction acceleration always synchronizes with the bunch circulation. This feature enables the realization of an almost injector-free synchrotron

Experimental Demonstration of the Induction Synchrotron

We report an experimental demonstration of the induction synchrotron, the concept of which has been proposed as a future accelerator for the second generation of neutrino factory or hadron collider. The induction synchrotron supports a superbunch and a superbunch permits more charge to be accelerated while observing the constraints of the transverse space-charge limit. By using a newly developedinduction acceleration system instead of radio-wave acceleration devices, a single proton bunch injected from the 500 MeV booster ring and captured by the barrier bucket created by the induction step voltages was accelerated to 6 GeV in the KEK proton synchrotron